PUZZLE_SETUP file format description

Many people share .puzzle_setup files without attaching instructions on how to use it. Yet it isn’t evident for everyone which program a .puzzle_setup file can be edited, converted or printed with. On this page, we try to provide assistance for handling .puzzle_setup files.

1 filename extension(s) found in our database.

.puzzle_setup - Foldit Puzzle Setup Data

The PUZZLE_SETUP game data files are related to Foldit. PUZZLE_SETUP file is a Foldit Puzzle Setup Data. Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding.

Game Data files
- / -
Foldit Puzzle Setup Data related extensions:
Foldit Molecules Data

Naturally, other applications may also use the .puzzle_setup file extension. Even harmful programs can create .puzzle_setup files. Be especially cautious with .puzzle_setup files coming from an unknown source!

Can't open a .puzzle_setup file?

When you double-click a file to open it, Windows examines the filename extension. If Windows recognizes the filename extension, it opens the file in the program that is associated with that filename extension. When Windows does not recognize a filename extension, you receive the following message:

Windows can't open this file:


To open this file, Windows needs to know what program you want to use to open it. Windows can go online to look it up automatically, or you can manually select one from a list of programs that are installed on your computer.

To avoid this error, you need to set the file association correctly.

Operating systems currently supports the following operating systems:

Windows XP/Vista, Windows 7/8, Windows 10, CentOS, Debian GNU/Linux, Ubuntu Linux, FreeBSD, Mac OS X, iOS, Android

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